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Dr.
Zavos has been a true pioneer! He has had a long career as a World
renowned authority in human reproduction, and is the chief scientist
in the development of numerous new and innovative ideas and technologies
in the human reproductive area with worldwide implications.
Below
is a list of pioneering ideas and technologies developed by Dr.
Zavos in the field of reproductive medicine and assisted reproductive
technologies.
| Attempted
the First Fresh Human Cloned Embryo Transfer for Reproductive
Purposes. |
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PRESS
RELEASE: FEBRUARY 2, 2004 |
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| Created
the first ever human cloned embryo for reproductive purposes.
Human
Reproductive Cloning: The Time is Near (RBM Online, 2003)
A
Clone at Last? (US News and World Report, April 21, 2003)
First
Proof of Cloned Embryo (Sunday Herald, Glasgow, April
6, 2003)
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Participated
in the establishment of the first IVF program in Kentucky
and the subsequent birth of the first IVF baby in the State
of Kentucky, USA, 1986.
TEST-TUBE
BABIES. -- June 18, 1986
TEST-TUBE BABIES. "1st 'test-tube' baby conceived in
Kentucky is born" The first "test-tube baby"
conceived in Kentucky was born yesterday to a Lexington couple
at the University of Kentucky Albert B. Chandler Medical Center.
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Participated
in the development and introduction of the first
Intra-Uterine Insemination (IUI) procedures in humans in the
World. This was done in collaboration with Dr. Melvin R. Cohen,
the Director of the Andrology Institute of Chicago, at Northwestern
University. The work was published during the International
Symposium on Human Artificial Insemination and Semen Preservation
in Paris, France, in 1979.
Zavos,
P.M. and Cohen, M.R.: Mucus penetration test as an assay
for frozen and fresh spermatozoa. International Symposium
on Human Artificial Insemination and Semen Preservation,
Paris, France. p. 52. April 9-11, 1979.
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Employment
of Test-Yolk buffer for semen refrigeration using human semen
Zavos, P.M., Goodpasture, J.C., Zaneveld, L.J.D. and Cohen,
M.R.: Motility and enzyme activity of human spermatozoa
stored for 24 hours at +5 C and -196 C. Fertil. Steril.,
34(16):607-609, 1980.
Zavos,
P.M.,
Correa, J.R., Foster, C.L., Massey, J.B., Zarmakoupis-Zavos,
P.N.: Fertilization potential and qualitative characteristics
of human spermatozoa after short-term cryostorage at 5C
in two different TEST-Yolk buffer preparations. Tohoku
Journal of Experimental Medicine, 184:1-10, 1998.
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Employment
of bovine cervical mucus as a bioassay for fresh and cryopreserved
human spermatozoa.
Zavos, P.M. and Cohen, M.R.: Bovine mucus penetration test:
An assay for fresh and cryopreserved human spermatozoa.
Fertil. Steril., 34(2):175-176, 1980.
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Employment
of supercooling as a means to cryostore spermatozoa.
Zavos,
P.M. and Graham, E.F. Supercooling effects on motility and
fertility of turkey spermatozoa as compared between two
different buffers. Cryo-Letters, 2:76-85, 1981.
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Employment
of emulsions and supercooling methods as a means to cryostore
spermatozoa.
Zavos,
P.M. and Graham, E.F. Preservation of turkey spermatozoa
by the use of emulsions and supercooling methods. Cryobiology,
18:497-505, 1981.
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Employment
of "seeding" to limit or prevent cryo-damage to cell suspensions
during freezing.
Zavos,
P.M. and Graham, E.F.: Effects of various degrees of supercooling
on motility and fertility of turkey spermatozoa. Cryo-Letters,
3:71-82, 1982.
Zavos,
P.M. and Graham, E.F.: Effects of various degrees of supercooling
and nucleation temperatures on fertility of frozen turkey
spermatozoa. Cryobiology, 20:553-559, 1983.
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Documentation
of the presence of opisthosmotic shock to frozen-thawed human
spermatozoa.
Zavos,
P.M.: Opisthosmotic shock of frozen-thawed human spermatozoa.
Infertility, 5(3):247-255, 1983.
Zarmakoupis-Zavos,
P.N., Correa, J.R., Aslanis, P., Antypas, S., Zavos,
P.M.: Occurrence of osmotic shock in human spermatozoa:
its effects on qualitative measurements in frozen-thawed
spermatozoa. Middle East Fertility Society Journal, 3(1):66-71,
1998.
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Employment
of a non-invasive technique for harvesting and reconstituting
retrograde ejaculates.
Zavos,
P.M. and Wilson, E. A.: Retrograde ejaculation: A new technique
for collection and reconstitution of retrograde ejaculate.
Infertility, 5(4):287-296, 1983.
Zavos,
P.M. and Wilson, E.A.: Ejaculation retrograde: etiologie
et traitement. Emploi d'une nouvelle technique. Contraception-
fertilite-sexualite, 12(6):813-818, 1984.
Zavos,
P.M. and Wilson, E.A.: Retrograde ejaculation: etiology
and treatment via the use of a new noninvasive method. Fertil.
Steril., 42(4):627-632, 1984.
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Employment
of seminal collection devices in order to enhance ejaculate
characteristics as compared to those ejaculates collected
via masturbation.
Zavos,
P.M.:
Characteristics of human ejaculates collected via masturbation
and a new Silastic seminal fluid collection device (SCD).
Fertil. Steril., 43(3):491-492, 1985.
Zavos,
P.M.: Seminal parameters of ejaculates collected
from oligospermic and normospermic patients via masturbation
and at intercourse with the use of a Silastic seminal fluid
collection device. Fertil. Steril., 44(4):517-520, 1985.
Zavos,
P.M.: Role de la stimulation sexuelle dans l'elaboration
de l'ejaculat chez l'homme. Contraception-fertilite-sexualite,
13(9):981-983, 1985.
Zavos,
P.M.: Comparisons between ejaculates collected
at intercourse and at masturbation. Young Couples International,
2:5, 1985.
Zavos,
P.M.: Parameters and improvements in ejaculates
collected at intercourse and the use of a silastic seminal
collection device vs masturbation. Infertility, 9(1):57-64,
1986.
Karagounis,
S.C., Papanikolaou, N.A. and Zavos, P.M.:
Semen parameters compared between smoking and non-smoking
men: smoking intensity and semen parameters. Infertility,
8(4): 373-382, 1985.
Zavos,
P.M.: Incidence des pertes de sperme au cours de
l'ejaculation provoquee' par masturbation. Contraception-fertilite-sexualite,
14(11):1003-1006, 1986.
Zavos,
P.M.: Treatment of ejaculatory and spermatogenic
dysfunctions in oligospermic patients via collection of
ejaculates at intercourse using a seminal fluid collection
device. Infertility, 10(2):167-171, 1987.
Zavos,
P.M.: Utilisation clinique d'un dispositif de recueil
du sperme (SCD); parametres seminaux et ameliorations d'ejaculats
recueillis par rapport sexuel avec le SCD et par masturbation,
chez des patients presentant divers dysfonctionnements spermatogenes
et ejaculatoires. Contraception-fertilite-sexualite, 16(6):475-481,
1988.
Zavos,
P.M., Goodpasture, J.C.: Clinical use of a seminal
collection device: improvements of specific seminal deficiencies
through use of a seminal collection device at intercourse
versus masturbation. Infertility, 11(4):289-304, 1988.
Zavos, P.M. and Goodpasture, J.C.: Clinical
improvements of specific seminal deficiencies via intercourse
with a seminal collection device versus masturbation. Fertil.
Steril. 51(1):190-193, 1989.
Zarmakoupis-Zavos,
P.N., Zarmakoupis, C.N., Correa, J.R., Zavos, P.M.:
Multiple ejaculate collection via the use of a semen collection
device at intercourse versus masturbation. Middle
East Fertility Society Journal, 4 (3): 228-232, 1999.
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Documentation
of the effects of smoking on seminal characteristics and sperm
parameters in humans.
Zavos,
P.M.: Cigarette smoking and human reproduction: Effects
on female and male fecundity. Infertility 12(1):35-46, 1989.
Zavos,
P.M.: Tabagisme: sterilite masculine et femenine. Contraception-fertilite-sexualite,
17(2):133-138, 1989.
Zavos,
P.M.,
Correa, J.R., Antypas, S., Zarmakoupis-Zavos, P.N., Zarmakoupis
C.N.: The effects of seminal plasma from cigarette smokers
on sperm viability and longevity. Fertility and Sterility,
69(3):425-429, 1998.
Zavos, P.M., Correa, J.R., Karagounis,
C.S., Ahparaki, A., Phoroglou, C.R., Hicks, C.H., Zarmakoupis-Zavos,
P.N.: An electron microscope study of the axonemal ultrastructure
in human spermatozoa from smoking and nonsmoking males.
Fertility and Sterility, 69(3):430-434, 1998.
Zavos,
P.M.: Cigarette smoking effects on human reproduction.
Journal of the Franklin Institute, 335(A):1-8, 1998.
Zavos,
P.M., Zarmakoupis, C.N. and Zarmakoupis-Zavos,
P.N.:The impact of cigarette smoking on human reproduction:
its effects on female and male fecundity. Middle East Fertility
Society Journal, 3(3):340-47, 1998.
Zavos,
P.M.: Impact of cigarette smoking on human reproduction:
Its effects on male and female fecundity. Technology, 6:9-16,
l999.
Zavos,
P.M. and Zarmakoupis-Zavos, P.N.: How smoking affects
reproductive health: Female fecundity. OBG Management, 2:48-55,
l999.
Zavos,
P.M.: Cigarette smoking and human reproduction: effects
on female and male fertility. American Council on Science
and Health (Special Report) 12(3):16-19,2000.
Karagounis,
C.S., Papanikolaou, N.A. and Zavos, P.M.: Cigarette smoking:
Smoking intensity and semen parameters in men. Proceedings
of the Fifth World Congress on Human Reproduction, Supplement,
pp.135-137, 1986.
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Introduction
of the first commercial and patented semen preparation device
for preparation of human sperm for IUI purposes.
Zavos, P.M. and Centola, G.M.: Qualitative and quantitative
improvements in human spermatozoa recovered via the swim-up
and a new semen filtration column (SFC) method. Infertility,
13(1):25-34, 1990.
Zavos,
P.M. and Centola, G.M.: Ameliorations seminales des spermatozoides
utilises pour la fecondation artificielle: Comparaison entre
la methode de "nage ascedante" et une nouvelle methode de
filtration du sperme sur colonne. Contraception-fertilite-sexualite,
18(11):943-948, 1990.
Zavos,
P.M.: Selection de spermatozoides viables a partit d'echantillons
de spermes humains congeles-decongeles: comparaison de la
methode du "swim-up" et d'une nouvelle methode de filtration
: le SpermPrep™. Contraception-fertilite-sexualite, 19(4):293-297,
1991.
Zavos,
P.M., Sofikitis, N., Toda, T. and Miyagawa, I.: Improvements
in qualitative characteristics of cryopreserved human spermatozoa
following recovery via the SpermPrep™II filtration method.
Tohoku J. Experimental Medicine. 163:283-290, 1991.
Zavos,
P.M.: Preparation of human frozen-thawed specimens using
the SpermPrep™ filtration method: Improvements over the
conventional swim-up method. Fertility and Sterility. 57(6):1326-1330,
1992.
Zavos,
P.M.: Amelioration des caracteristiques qualitatives des
spermatozoides humains cryoconserves apres recuperation
par la methode de filtration SpermPrep™II. Contraception-fertilite-sexualite.
20(5):541-545, 1992.
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Employment
of the hypoosmotic swelling test (HOS) to assess functional
integrity of equine sperm membrane.
Zavos,
P.M.: The use of hypoosmotic swelling test (HOS) to assess
functional integrity of equine sperm membrane. J. Assisted
Reproductive Technology-Andrology. 2(2):215-216, 1991.
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Introduction
of the first standardized and patented technology for in-office
use for semen preparation for IUI purposes.
Zavos,
P.M.: Improvements in qualitative and quantitative characteristics
of human spermatozoa using the Swim-up method and a new
standardized Rise-Kit™ technique. Molecular Andrology. 4:231-239,
1992.
Zavos,
P.M., Zarmakoupis-Zavos, P.N. Correa, J.R., Aslanis,
P., Zarmakoupis, C.N.: Assessment of two devices for in
vitro preparation of human sperm. Archives of Andrology,
45(2):85-90, 2000.
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Employment
of round spermatid injections for treatment of patients with
non-obstructive azoospermia.
Sofikitis,
N., Toda, T., Miyakawa, I., Zavos, P.M., Pasyianos, P.,
Mastelu, E.: Beneficial effects of electrical stimulation
before round spermatid nuclei injections into rabbit oocytes
on fertilization and subsequent embryonic development. Fertility
Sterility. 65(1):176-185, 1996.
Zavos, P.M., Barnes, F.L., Correa, J.R., Zarmakoupis-Zavos,
P.N., Tesarik, J.: Methods for isolation and purification
of post-ejaculate human round spermatids for possible use
in intracytoplasmic round spermatid injection. Middle East
Fertility Society Journal. 2:147-150, 1997.
Zavos,
P.M.: Methods for isolation and purification of
post-ejaculate human round spermatids for possible use in
intracytoplasmic round spermatid injection. Proceedings
of the 5th International Congress on Advances
in Assisted Reproduction Technologies in the Year 2000.
Rome, Italy, p. 12-12/1, 1997.
Zavos,
P.M., Antypas, S., Aslanis, P., Zarmakoupis, C.N
and. Zarmakoupis-Zavos, P.N.: Development of hyperosmotic
shrinkage test to measure the functional integrity of the
membrane of human round spermatids retrieved from testes
for use in ICSI. Middle East Fertility Society Journal,
5 (2), 115-119, 2000.
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Use
of nonoxynol-9 co-precipitated formulations with polyvinylpyrrolidone
in rabbits as possible vaginal contraceptives in humans.
Zavos,
P.M., Correa,
J.R.: Vaginal delivery of new formulations of nonoxynol-9
co-precipitated with polyvinylpyrrolidone in rabbits: comparisons
between two formulation-delivery systems. Contraception.
56(2):123-127, 1997.
Zavos,
P.M., Correa, J.R., Zarmakoupis-Zavos, P.N.: Assessment
of a tablet drug delivery system incorporating nonoxynol-9
co-precipitated with polyvinylpyrrolidone in preventing
the onset of pregnancy in rabbits. Fertility and Sterility,
69(4):768-73, 1998.
Digenis,
G.A., Nosek, D., Mohammadi., F., Darwzeh, N.B., Anwar, H.S.
and Zavos, P.M.: Novel vaginal controlled
delivery systems incorporating coprecipitates of nonoxynol-9.
Pharmaceutical Development and Technology, 4(3):421-430,
1999.
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Introduction
of the Viscolytic System (VLS), a commercial product for treatment
of seminal viscosity difficulties.
Zavos, P.M., Correa, J.R., Zarmakoupis-Zavos,
P.N.: Effect of treatment of seminal viscosity difficulties
with -chymotrypsin on the recovery of spermatozoa for assisted
reproductive technologies: comparisons between the SpermPrep™
filtration and Percoll gradient centrifugation methods.
Middle East Fertility Society Journal,2 (3):223-29,
1997.
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Employment
of Test Yolk buffer (TYB) as a means to treat antisperm antibodies
in humans
Zavos,
P.M., Correa, J.R., Zarmakoupis-Zavos, P.N.: Antisperm
antibody treatment mode: levels of antisperm antibodies
following incubation in TEST-Yolk buffer and filtration
via the SpermPrep™II method. Fertility and Sterility, 69(3):517-21,
1998.
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Introduction
of the first commercial liquid semen shipper for transporting
unfrozen semen to a location for evaluation purposes or for
use in an insemination program or for other Assisted Reproductive
Techniques (ART) such as In-Vitro Fertilization (IVF).
Zavos,
P.M., Correa, J.R., Clark, W., Zarmakoupis-Zavos,
P.N.:Sperm viability in human semen specimens cryostored
at 5°C using the Bio-Tranz™ container system for semen transport.
Middle East Fertility Society Journal, 3(3): 325-329, 1998.
Zavos,
P.M., Kaskar, K., Zarmakoupis-Zavos, P.N.: Evaluation
of human semen specimens transported at 5°C using the Bio-Tranz™
shipping system. The 25th Annual Meeting of the
American Society of Andrology, Boston, MA, USA; April 7-11,
2000.
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Introduction
of the first standardized and patented multi-chamber technology
for the recovery of high quality spermatozoa for IUI or other
forms of assisted reproductive technologies.
Zavos,
P.M., Abou Abdallah, M., Aslanis, P., Correa, J.R.,
Zarmakoupis-Zavos, P.N.: Use of the Multi-ZSC™ One-Step
Standardized Swim-Up Method: Recovery of High Quality Spermatozoa
for IUI or Other Forms of Assisted Reproductive Technologies.
Fertil. Steril. 74 (4), 834-835, 2000.
Correa-Pérez,
J.R., Torres-Santiago, O, Fernández-Pelegrina, R.,
Zavos , P.M.: Sperm characteristics recovered
from teratozoospermic specimens using a multi-layer swim-up
column. The 25th Annual Meeting of the American
Society of Andrology, Boston, MA, USA; April 7-11, 2000.
Zavos,
P.M., Kaskar, K., Zarmakoupis-Zavos, P.N.: Evaluation
of the Multi-ZSC column in selecting high quality sperm
from normozoospermic samples. The 16th Annual
Meeting of the European Society of Human Reproduction and
Embryology, Bologna, Italy, June 25-28, 2000.
Correa-Pérez,
J.R., Torres-Santiago, O., Fernández-Pelegrina, R.,
Zarmakoupis-Zavos, P.N., Zavos, P.M.: Sperm
quantitative/qualitative characteristics distribution of
normozoospermic and teratozoospermic specimens in a multi-layer
swim-up column. The 56th Annual Meeting of the
American Society for Reproductive Medicine, San Diego, CA,
USA, October 21-25, 2000.
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Introduced
for the first time the aging effect in human males
Zavos,
P.M., Kaskar, K., Correa, J.R., Sikka, S.C., Zarmakoupis-Zavos,
P.N.: Seminal characteristics of men of different age groups:
Is there an aging effect? The 56th Annual Meeting
of the American Society for Reproductive Medicine, San Diego,
CA, USA, October 21-25, 2000. (Requested
for Press Release by ASRM)
Zavos,
P.M., Aslanis, P., Kaskar, K., Correa, J.R., Zarmakoupis-Zavos,
P.N.: The aging effect of men on sexual behavior and seminal
characteristics: Fact or fiction? The 4th Panhellenic Andrology
Meeting, Athens, Greece, November 10-12, 2000. (Received
the Outstanding Clinical Research Award)
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Introduced
for the first time the impact of smoking has on the couples
ability to reproduce and the impact of cigarette smoking on
male and female sexual behavior.
Zavos,
P.M., Zarmakoupis, C.N., Correa, J.R., Zarmakoupis-Zavos,
P.N.: The impact of cigarette smoking on male and female
sexual behavior: comparisons between smoking and non-smoking
couples. The 56th Annual Meeting of the American
Society for Reproductive Medicine, San Diego, CA, USA, October
21-25, 2000.
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